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Journal of Healthcare Engineering
Volume 2017, Article ID 7862672, 9 pages
Research Article

Computer-Aided Clinical Trial Recruitment Based on Domain-Specific Language Translation: A Case Study of Retinopathy of Prematurity

1School of Management and E-Business, Zhejiang Gongshang University, Hangzhou, Zhejiang 310018, China
2Pediatric Retinal Surgery Department, Shenzhen Eye Hospital, Shenzhen Key Ophthalmic Laboratory, The Second Affiliated Hospital of Jinan University, Shenzhen, Guangzhou 518040, China
3Management School, Hangzhou Dianzi University, Hangzhou, Zhejiang 310018, China

Correspondence should be addressed to Yinsheng Zhang; nc.ude.usgjz@sygnahz, Guoming Zhang; moc.361@gnimoug-gnahz, and Qian Shang; moc.361@zwx_naiqgnahs

Received 10 November 2016; Accepted 5 February 2017; Published 5 April 2017

Academic Editor: Xiang Li

Copyright © 2017 Yinsheng Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Reusing the data from healthcare information systems can effectively facilitate clinical trials (CTs). How to select candidate patients eligible for CT recruitment criteria is a central task. Related work either depends on DBA (database administrator) to convert the recruitment criteria to native SQL queries or involves the data mapping between a standard ontology/information model and individual data source schema. This paper proposes an alternative computer-aided CT recruitment paradigm, based on syntax translation between different DSLs (domain-specific languages). In this paradigm, the CT recruitment criteria are first formally represented as production rules. The referenced rule variables are all from the underlying database schema. Then the production rule is translated to an intermediate query-oriented DSL (e.g., LINQ). Finally, the intermediate DSL is directly mapped to native database queries (e.g., SQL) automated by ORM (object-relational mapping).