TY - JOUR A2 - Katsanis, John S. AU - Channasanon, Somruethai AU - Udomkusonsri, Pareeya AU - Chantaweroad, Surapol AU - Tesavibul, Passakorn AU - Tanodekaew, Siriporn PY - 2017 DA - 2017/08/20 TI - Gentamicin Released from Porous Scaffolds Fabricated by Stereolithography SP - 9547896 VL - 2017 AB - Porous oligolactide-hydroxyapatite composite scaffolds were obtained by stereolithographic fabrication. Gentamicin was then coated on the scaffolds afterwards, to achieve antimicrobial delivery ability to treat bone infection. The scaffolds examined by stereomicroscope, SEM, and μCT-scan showed a well-ordered pore structure with uniform pore distribution and pore interconnectivity. The physical and mechanical properties of the scaffolds were investigated. It was shown that not only porosity but also scaffold structure played a critical role in governing the strength of scaffolds. A good scaffold design could create proper orientation of pores in a way to strengthen the scaffold structure. The drug delivery profile of the porous scaffolds was also analyzed using microbiological assay. The release rates of gentamicin from the scaffolds showed prolonged drug release at the levels higher than the minimum inhibitory concentrations for S. aureus and E. coli over a 2-week period. It indicated a potential of the scaffolds to serve as local antibiotic delivery to prevent bacterial infection. SN - 2040-2295 UR - https://doi.org/10.1155/2017/9547896 DO - 10.1155/2017/9547896 JF - Journal of Healthcare Engineering PB - Hindawi KW - ER -