Predicting Interactions between Virus and Host Proteins Using Repeat Patterns and Composition of Amino Acids

Table 6

Results of independent testing our SVM on PPIs of new viruses with human.

Virus	Sn (%)	Sp (%)	Acc (%)	PPV (%)	NPV (%)	MCC	AUC
HCV	94.37	52.04	73.20	66.30	90.24	0.512	0.925
SARS virus	96.67	73.33	85.00	78.38	95.65	0.720	0.970
H1N1 virus	90.72	67.90	79.31	73.87	87.97	0.602	0.938
HPV-16	81.82	94.04	87.93	93.21	83.80	0.764	0.938
HIV-1	87.83	64.64	76.24	71.30	84.16	0.539	0.882
Average	90.28	70.39	80.34	76.61	88.36	0.627	0.930

Sn: sensitivity, Sp: specificity, Acc: accuracy, PPV: positive predictive value, NPV: negative predictive value, MCC: Matthews correlation coefficient, and AUC: the area under the ROC curve.