Injectable Nanocurcumin-Formulated Chitosan-g-Pluronic Hydrogel Exhibiting a Great Potential for Burn Treatment

Schematic 1

Proposal process of nCur-CP nanocomposite hydrogel for burn wound healing. (a) CP is synthesized through the conjugation of pluronic F127 and amide groups on chitosan at the specific ratios (pluronic F127 : chitosan = 15 : 1 in weight). (b) Curcumin in process into nanoform by the help of CP resulting in the formation of nCur-CP nanocomposite hydrogel (c) which has the sol-gel transition near the temperature of human body; thus, this solution is in gelation after contacting with wound surface (d). (e) nCur-CP nanocomposite hydrogel could be a promising therapeutic strategy for the management of burn wound.