Raman Spectroscopy and Aptamers for a Label-Free Approach: Diagnostic and Application Tools

Table 2

Schematic summary of studies focused on label-free Raman signal of α-thrombin captured by 15-TBA.

Diagnostic peaks (cm⁻ˡ)	Enhancer	Method of analysis	Concentration	References
1140: C-N stretching of THR; 1540: Amide II; 1635: Amide I	AgNPs	Wet	10 µM	[68]
822: 2′deoxyribose; 1140: C-O-C stretch; 1150: guanine ring modes	AuNPs	Wet	10 nM	[70]
According to Ochsenkuhn and Campbell [70]	Au nanostructured substrate	Dry	0.1 nM	[71]