Cloud-Based Brain Magnetic Resonance Image Segmentation and Parcellation System for Individualized Prediction of Cognitive Worsening

Table 1

Demographics and characteristics of the training dataset (ADNI1).

Diagnosis at baseline	N	Age	Sex (men/women)	MMSE at baseline	MMSE after 2 years	MMSE decline in 2 years	Number of patients with substantial worsening
CN	151	75.5 ± 5.0	80/71	29.2 ± 1.0	29.0 ± 1.2	−0.2 ± 1.3	1
MCI	176	73.4 ± 7.1	113/63	27.2 ± 1.7	25.4 ± 3.9	−1.8 ± 3.3	46
AD	75	73.8 ± 7.4	34/41	23.3 ± 2.0	19.0 ± 5.6	−4.3 ± 5.3	36
Total	402	74.9 ± 6.5	227/175	27.2 ± 2.6	25.6 ± 5.1	−1.6 ± 3.6	83

Substantial worsening: MMSE declines ≤ −4 within two years.