Astragaloside IV Reduces OxLDL-Induced BNP Overexpression by Regulating HDAC

Figure 2

Comparison of BNP mRNA and protein expression levels in each group. (a) The expression level of BNP mRNA in HL-1 cells of blank control group, OxLDL intervention group, OxLDL + low dose astragaloside IV (12.5 µM) treatment group, and OxLDL + high-dose astragaloside IV (50 µM) treatment group. (b) Western blot results of BNP protein in HL-1 cells of blank control group, OxLDL intervention group, OxLDL + low dose astragaloside IV (12.5 µM) treatment group, and OxLDL + high-dose astragaloside IV (50 µM) treatment group (indicates  < 0.001; NS: no significance; n = 5).

(a)

(b)