GNAO1 as a Novel Predictive Biomarker for Late Relapse in Hepatocellular Carcinoma

Table 2

Cox survival analysis of GNAO1 protein level and clinicopathological parameters in 79 HCC patients

Parameters	Univariate		Multivariate
	HR (95% CI)	value	HR (95% CI)	value
GNAO1 level (low vs. high)	0.512 (0.297–0.882)	0.016	0.420 (0.237–0.744)	0.003
Age (years) (<60 vs. ≥60)	0.947 (0.498–1.800)	0.868
Sex (male vs. female)	1.442 (0.680–3.057)	0.340
HBV infection (yes vs. no)	0.821 (0.445–1.514)	0.527
AFP (ng/mL) (<200 vs. ≥200)	0.672 (0.392–1.153)	0.149
Liver cirrhosis (yes vs. no)	0.841 (0.474–1.492)	0.553
Tumor location (left vs. right)	1.101 (0.644–1.881)	0.725
Maximum tumor size (mm) (<30 vs. ≥30)	1.156 (0.545–2.452)	0.706
Number of tumors (1 vs. ≥2)	0.853 (0.340–2.144)	0.736
Tumor type (lump vs. nodular)	0.590 (0.213–1.683)	0.311
Vascular invasion (yes vs. no)	1.245 (0.718–2.157)	0.436
TNM stage (I-II vs. III-VI)	1.959 (1.055–3.638)	0.033	2.581 (1.345–4.954)	0.004

Abbreviations: HCC: hepatocellular carcinoma, HR: hazard ratio, CI: confidence interval, HBV: hepatitis B virus, AFP: alpha-fetoprotein, TNM: tumor-node-metastasis. , .