[Retracted] MiR-483 Promotes Colorectal Cancer Cell Biological Progression by Directly Targeting NDRG2 through Regulation of the PI3K/AKT Signaling Pathway and Epithelial-to-Mesenchymal Transition

Figure 3

MiR-483 regulated the expression of NDRG2 through binding to NDRG2 mRNA 3′-UTR. (a) TargetScan predicted NDRG2 was a target gene of miR-483 and the binding site was located at the 3′-UTR of NDRG2 mRNA. (b) The luciferase reporter assay indicated that miR-483 directly targeted NDRG2 in LOVO cells. (c) Overexpression of miR-483 enhanced the mRNA level of NDRG2, while the knockdown of miR-483 inhibited the expression of NDRG2 in LOVO cells. ; .: wild type; MUT: mutant type.

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