Mitofusin-2 Restrains Hepatic Stellate Cells’ Proliferation via PI3K/Akt Signaling Pathway and Inhibits Liver Fibrosis in Rats

Figure 7

The expressions of p-PDGFR-β, α-SMA, and Col-1 decreased under the administration of Mfn-2 at early stage of hepatic fibrosis. (a) Western blot showed that the protein expressions of p-PDGFR-β, TGF-β1, α-SMA, and Col-1 markedly decreased under the administration of Mfn-2, and such effects were significantly related to actuation duration of Ad-Mfn-2. (b–d) Immunohistochemical staining indicated that protein expressions of p-PDGFR-β, α-SMA, and Col-1 markedly decreased and restricted in portal area under the administration of Mfn-2 (magnification × 200).

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