Effect of Controlled Microtopography on Osteogenic Differentiation of Mesenchymal Stem Cells

<table class="table-group" id="tab4"><tr><td><table class="table"><tr><td class="thead-hr" colspan="6"><hr/></td></tr><tr class="thead"><td class="align_left">Material</td><td class="align_center">Shape</td><td class="align_center">Depth (<i>μ</i>m)</td><td class="align_center">Side length<br/>/diameter (<i>μ</i>m)</td><td class="align_center">Cell type</td><td class="align_center">Main results</td></tr><tr><td class="thead-hr" colspan="6"><hr/></td></tr><tr><td class="align_left">PS</td><td class="align_center">Square and round</td><td class="align_center">10</td><td class="align_center">10, 25, and 50</td><td class="align_center">Ad-MSCs</td><td class="align_center">Square micropit with a side length of 50 <i>μ</i>m shows advantages over round-shaped micropits</td></tr><tr><td class="align_left">PDMS</td><td class="align_center">Square</td><td class="align_center">2 and4</td><td class="align_center">3</td><td class="align_center">mMSCs</td><td class="align_center">Cells on the substrates has enhanced FAs, actin polymerization, and osteogenic differentiation</td></tr><tr><td class="align_left">Zirconia</td><td class="align_center">Round</td><td class="align_center">3 and 10</td><td class="align_center">10, 20, and 30</td><td class="align_center">hMSCs</td><td class="align_center">Pits with 30 <i>μ</i>m diameter and 10 <i>μ</i>m deep may significantly promote MSCs commitment towards the osteoblastic phenotype</td></tr><tr class="table-tr"><td colspan="6"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td><div>PS, polystyrene.<br/></div></td></tr></table>

<div>Summary of MSC differentiation regulated by micropit.</div>

Journal of Healthcare Engineering

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Table 4

Table 4: Effect of Controlled Microtopography on Osteogenic Differentiation of Mesenchymal Stem Cells 