[Retracted] Functional New Transcription Factors (TFs) Associated with Cervical Cancer

Figure 1

EMX2 is downregulated in cervical cancer. (a) Heatmap of 20 transcription factor genes (8 upregulated and 12 downregulated) generated using package pheatmap (version 1.0.12) in R (version 4.0.0) software according to value. The number in each cell represents logarithmic fold change in each dataset calculated by the limma R package. Each row in the heatmap represents one gene and each column indicates one dataset. Red indicates upregulation and blue represents downregulation. (b) Gene Expression Profiling Interactive Analysis (GEPIA) was performed to validate the differential expression of transcription factor in cervical cancer samples compared with normal samples in TCGA and GTEx dataset. The expression level from GEPIA was presented as log₂(TPM + 1). The boxplots were generated directly from GEPIA2 (Expression DIY, Expression on Box Plots). Red box was the cancer tissue group, gray was the normal tissue group, and asterisk represented  < 0.01. The dots represented expression in each sample. (c) GEPIA2 Survival Plots for EMX2 mRNA expression association with overall survival in TCGA-CESC. (d) Pathological Stage Plot for EMX2 expressions in different stage of TCGA-CESC samples. GTEx, Genotype-Tissue Expression; RRA, Robust Rank Aggregation; TCGA, The Cancer Genome Atlas; TPM, transcripts per million.

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