Figure 2: Period required to reach a ratio of wound area of 0.15. The period required to reach this ratio in the OVX + 17 -estradiol group was significantly shorter than that in the SHAM and OVX groups. However, there were no significant differences between the SHAM and OVX groups. Values are expressed as mean ± SD, for each group, ANOVA, Tukey-Kramer. : versus the OVX + 17 -estradiol group.