Table of Contents
Journal of Inorganic Chemistry
Volume 2014, Article ID 268383, 11 pages
http://dx.doi.org/10.1155/2014/268383
Research Article

Complexation of Oxovanadium(IV) and Dioxouranium(VI) with Synthesized 1,2-(Diimino-4′-antipyrinyl)-1,2-diphenylethane Schiff Base: A Thermodynamic, Kinetic, and Bioactivity Investigation

Department of Chemistry, University of Kashmir, Hazratbal, Srinagar, Jammu and Kashmir 190006, India

Received 28 June 2014; Revised 22 September 2014; Accepted 7 October 2014; Published 28 December 2014

Academic Editor: Radhey Srivastava

Copyright © 2014 Shabnum Bashir et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We report the comparative synthetic methodologies and characterization of a tetradentate Schiff base ligand 1,2-(diimino-4′-antipyrinyl)-1,2-diphenylethane (DE). The target synthesis of oxovanadium(IV) and dioxouranium(VI) complexes (vanadyl and uranyl) with the (DE) ligand was also attempted to envisage the effect of metal ion steric factor on complexation process through solution phase thermodynamic and kinetic studies. The thermodynamic stabilities of synthesized vanadyl and uranyl (DE) complexes are discussed in light of their solution phase thermodynamic stability constants obtained by electroanalytical method. A comparative kinetic profile of vanadyl and uranyl complexation with DE is also reported. The complexation reaction proceeds with an overall 2nd order kinetics with both metal ions. Temperature dependent studies of rate constants present an activation energy barrier of ca. 40.913 and 48.661 KJ mol−1, for vanadyl and uranyl complexation, respectively, highlighting the metal ion steric and ligand preorganization effects. The synthesized Schiff base ligand and its vanadyl and uranyl complexes were screened for biocidal potential as antibacterial, antifungal, and anthelmintic agents with the results compared to corresponding reference drugs.