Table of Contents
Journal of Inorganic Chemistry
Volume 2014 (2014), Article ID 769573, 10 pages
http://dx.doi.org/10.1155/2014/769573
Research Article

Copper(II) Complexes of 2-(Methylthiomethyl)anilines: Spectral and Structural Properties and In Vitro Antimicrobial Activity

1Department of Chemistry, Rhodes University, P.O. Box 90, Grahamstown 6140, South Africa
2Faculty of Pharmacy, Rhodes University, P.O. Box 90, Grahamstown 6140, South Africa
3Department of Chemistry, Nelson Mandela Metropolitan University, Port Elizabeth 6001, South Africa

Received 23 December 2013; Accepted 13 February 2014; Published 16 April 2014

Academic Editor: Roman Boča

Copyright © 2014 Temitope E. Olalekan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Copper(II) complexes of 2-(methylthiomethyl)anilines (1a1f) have been obtained and characterized by elemental analyses, IR, electronic spectra, conductivity, and X-ray crystallography. The complexes (2a2f) have the structural formula [CuCl2L] with the bidentate ligand coordinating through sulfur and nitrogen. The single crystal X-ray diffraction data reveal that the copper complex (2f) has a tetragonally distorted octahedral structure with long Cu–Cl equatorial bonds. Magnetic susceptibility measurements indicate the availability of one unpaired electron in the complexes and the conductivity measurements in DMF show their behaviour as nonelectrolytes. The solid reflectance spectra and the electronic spectra of the complexes in DMSO were determined. The ligands and their copper complexes were screened for in vitro antimicrobial activity against S. aureus, B. subtilis, E. coli, and C. albicans. The methoxysubstituted complex (2c) showed more promising antibacterial activity against S. aureus and B. subtilis than other compounds at the concentration tested.