D. Dunon, J. Salomonsen, K. Skjødt, J. Kaufman, B. A. Imhof, "Ontogenic Appearance of MHC Class I (B-F) Antigens During Chicken Embryogenesis", Journal of Immunology Research, vol. 1, Article ID 075158, 9 pages, 1990. https://doi.org/10.1155/1990/75158
Ontogenic Appearance of MHC Class I (B-F) Antigens During Chicken Embryogenesis
Expression of chicken MHC class (B-F) antigens during ontogeny was determined by binding of anticlass antibody and appearance of B-F transcripts by Northern blotting in chicken organs during embryogenesis until 2 weeks after hatching. MHC class transcripts first become detectable in day 6.5 of embryogenesis. B-F cell-surface expression first becomes detectable in hemopoietic organs by day 10‑12 of embryogenesis and somewhat later in nonhemopoietic organs. Flow cytometry analysis of hemopoietic cells throughout embryogenesis revealed B-Fhi and B-F1 cell populations. The percentage of B-F cells in spleen and bone marrow decreased around hatching, which could reflect either cell flows in these organs during this period or the sensitivity of hemopoietic cells to hatching stress.
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