Journal of Immunology Research

Journal of Immunology Research / 1990 / Article

Open Access

Volume 1 |Article ID 075158 |

D. Dunon, J. Salomonsen, K. Skjødt, J. Kaufman, B. A. Imhof, "Ontogenic Appearance of MHC Class I (B-F) Antigens During Chicken Embryogenesis", Journal of Immunology Research, vol. 1, Article ID 075158, 9 pages, 1990.

Ontogenic Appearance of MHC Class I (B-F) Antigens During Chicken Embryogenesis

Received13 Jun 1990
Accepted19 Jul 1990


Expression of chicken MHC class (B-F) antigens during ontogeny was determined by binding of anticlass antibody and appearance of B-F transcripts by Northern blotting in chicken organs during embryogenesis until 2 weeks after hatching. MHC class transcripts first become detectable in day 6.5 of embryogenesis. B-F cell-surface expression first becomes detectable in hemopoietic organs by day 10‑12 of embryogenesis and somewhat later in nonhemopoietic organs. Flow cytometry analysis of hemopoietic cells throughout embryogenesis revealed B-Fhi and B-F1 cell populations. The percentage of B-F cells in spleen and bone marrow decreased around hatching, which could reflect either cell flows in these organs during this period or the sensitivity of hemopoietic cells to hatching stress.

Copyright © 1990 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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