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Developmental Immunology
Volume 2, Issue 1, Pages 1-6

Changes in the Amphibian Antibody Repertoire are Correlated With Metamorphosis and not With Age or Size

1Department of Biology, New York University, New York 10003, NY, USA
2The Basel Institute for Immunology, 487 Grenzacherstrasse, Basel 4005, Switzerland

Copyright © 1992 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Tadpole and adult Xenopus, manipulated to be of comparable size, exhibited stagespecific antibody expression. The production of adult-type higher-affinity anti-DNP antibodies proved to be independent of the age and size of the individual and is concomitant with the completion of metamorphosis. The appearance of new antibody specificities at such a time suggests that their expression occurs with the cell turnover and renewal during a period of morphological changes.