Developmental Immunology
Volume 6 (1998), Issue 1-2, Pages 3-11
http://dx.doi.org/10.1155/1998/21095
Langerhans Cell Migration in Murine Cutaneous Leishmaniasis: Regulation by Tumor Necrosis Factor α
Interleukin-1 β
, and Macrophage Inflammatory Protein-1α
1Research Center for Infectious Diseases, University of Würzburg, Würzburg D-97070, Germany
2Research Center for Infectious Diseases, University of Würzburg, Röntgenring 11, Würzburg D-97070, Germany
Received 16 August 1996; Accepted 14 August 1997
Copyright © 1998 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
After intradermal infection of mice with the obligatory intracellular parasite Leishmania major, Langerhans cells (LC) are intimately involved in the induction of the primary T-cell immune response. LC can phagocytose Leishmania and transport ingested parasites from the infected skin to the regional lymph nodes. Since TNF