Journal of Immunology Research

Journal of Immunology Research / 1998 / Article
Special Issue

12th International Conference on Lymphoid Tissues and Germinal Centres in Immune Reactions: Part 2

View this Special Issue

Open Access

Volume 6 |Article ID 076963 |

Bernhard Ryffel, Michel Le Hir, Mathias Müller, Hans-Pietro Eugster, "Correction of the TNF-LTα-Deficient Phenotype by Bone Marrow Transplantation", Journal of Immunology Research, vol. 6, Article ID 076963, 9 pages, 1998.

Correction of the TNF-LTα-Deficient Phenotype by Bone Marrow Transplantation

Received05 Aug 1996
Accepted03 May 1997


Mice with inactivated TNF-LTα genes have profound abnormalities of the immune system with hypoimmunoglobulinaemia, lack of lymph nodes, undifferentiated spleen, and defective Ig class switch. Transplantation of bone marrow cells from wild-type mice restored the synthesis of TNF, corrected the splenic microarchitecture, repopulated the lamina propria with IgA-producing plasma cells, and normalized the serum immunoglobulin levels of TNF-LTα deficient mice. Furthermore, the formation of germinal centers in the spleen and the defective Ig class switch in response to a T-cell-dependent antigen is corrected. These data demonstrate that most TNFproducing cells are bone-marrow-derived, and that the immunodeficiency due to TNF-LTα deletion can be corrected to a large extent by normal bone marrow, cell transplantation.

Copyright © 1998 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

More related articles

 PDF Download Citation Citation
 Order printed copiesOrder