The Protective Effects of Ultraviolet A1 Irradiation on Spontaneous Lupus Erythematosus-Like Skin Lesions in MRL/lpr Mice
Figure 1
Macroscopic and histopathological findings of the skin representative of MRL/lpr mice. (a), (d): nonlesional skin of nonirradiated mice. (b), (e): spontaneous LE-like skin lesion of nonirradiated mice. (c), (f): nonlesional skin of UVA1-irradiated (10 J/c) mice. As shown in Table 1, some of the nonirradiated MRL/lpr mice developed LE-like skin lesions with alopecia and scab formation (b). In the spontaneous LE-like skin lesions, histopathologically, acanthosis with hyperkeratosis, liquefaction, and mononuclear cell infiltrations into the dermis were noted (e). On the other hand, none of the UVA1-irradiated mice showed LE-like skin lesions (c). Most of the nonlesional mice did not show any histological changes (d), (f). (d), (e), (f): HE stain, original magnification, .
