Mizoribine: A New Approach in the Treatment of Renal Disease

Table 5

Adverse reactions to MZB.

	Renal Transplantation	Lupus Nephritis	Rheumatoid Arthritis	Nephrotic Syndrome	Total
Number of surveyed cases	916	275	3478	240	4909
Number of adverse reaction cases	186	33	462	38	719
Number of adverse reaction episodes	229	47	658	49	983
Incidence of adverse reaction cases	20.31%	12.00%	13.28%	15.83%	14.65%
Incidence of Adverse Reactions (%)
Blood
Leukopenia	6.99	2.55	0.20	0.83	1.63
Thrombocytopenia	0.98	0.73	0.14		0.33
Anaemia	0.44	0.36	0.72	0.42	0.63
Infection
Pneumonia	0.55		0.03	0.42	0.14
Mycosis pulmonary	0.55				0.10
Herpes zoster	0.76	1.45	0.17		0.35
Other viral infection	0.76		0.03		0.16
Liver
Hepatic function abnormal	4.15	1.09	1.18	2.29	1.81
Hypersensitivity
Rash		1.09	1.64	2.08	1.32
Prurigo			1.09		0.77
Metabolic
Uric acid increased	1.64	1.45	0.43	2.50	0.81
Gastrointestinal
Celialgia		0.36	2.21	1.67	1.67
Anorexia	0.98	1.09	1.12	0.83	1.08
Vomiting	0.55	1.09	1.18	0.42	1.02
Nausea	0.11	1.09	0.23		0.24
Diarrhea	0.22	0.73	0.63	0.42	0.55
Stomatitis	0.76	0.73	0.66	0.42	0.67
Skin
Epilation	1.09	1.09	0.29	1.67	0.55

Note. Listed adverse reactions occurred in 0.5% of cases of greater for at least one indication of MZR.