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Clinical and Developmental Immunology
Volume 2010, Article ID 137320, 17 pages
http://dx.doi.org/10.1155/2010/137320
Research Article

Changes of Immunological Profiles in Patients with Chronic Myeloid Leukemia in the Course of Treatment

1Department of Immunology and Microbiology, 1st Medical Faculty, Charles University, and the General Teaching Hospital in Prague, Karlovo náměstí 32, 121 11 Prague 2, Czech Republic
2Department of Clinical Biochemistry and Laboratory Medicine, 1st Medical Faculty, Charles University, Karlovo náměstí 32, 121 11 Prague 2, Czech Republic
3Clinical Department, Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20 Prague 2, Czech Republic
4Department of Immunology, 2nd Medical Faculty, Charles University, V Úvalu 84, 150 06 Prague 5, Czech Republic
5Department of Biostatistics, National Institute of Health, Šrobárova 48, 100 00 Prague 10, Czech Republic
6Department of Experimental Virology, Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20 Prague 2, Czech Republic

Received 28 June 2010; Revised 15 September 2010; Accepted 20 October 2010

Academic Editor: Stuart Berzins

Copyright © 2010 Zuzana Humlová et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In the previous paper of ours we compared, prior to start any treatment, a number of immunological parameters in 24 chronic myeloid leukemia patients with the same number of healthy subjects matched by age and sex. We found significant differences in the levels of immunoglobulins, the C4 component of complement, the C-reactive protein, interleukin 6, the composition of lymphocyte population and the production of some cytokines by stimulated CD3+ cells. Eleven of these patients were followed longitudinally. After treatment with hydroxyurea, interferon alpha, imatinib mesylate and dasatinib, or various combinations thereof, hematological remission was achieved in all patients and complete cytogenetic remission in nine of them. There was a nearly general tendency towards normalization of the abnormalities observed in the patients at their enrollment.