The SSX Family of Cancer-Testis Antigens as Target Proteins for Tumor Therapy

Table 2

Expression of SSX family members in cancers of different histological types. The expression of SSX family members 1–10 are shown for 24 cancers of varying histological origin and in normal testis tissue. “+” indicates that the presence of SSX mRNA or protein has been detected in these tumor tissues.

	SSX1	SSX2	SSX3	SSX4	SSX5	SSX6	SSX7	SSX8	SSX9	SSX10	References
Bladder cancer	+	+		+							[76]
Breast cancer	+	+		+							[22, 76–78]
Cholangiocarcinoma				+							[79]
Colorectal carcinoma	+	+		+	+						[22, 76, 80]
Endometrial cancer	+	+		+	+						[76]
Gastric carcinoma		+		+							[22, 76, 78]
Glioma		+		+							[22, 76]
Head and neck cancer	+	+		+	+						[76]
Hepatocellular carcinoma	+	+		+	+						[22, 81]
Hodgkin’s lymphoma	+	+		+							[82]
Leiomyosarcoma											[76]
Lymphoma/Leukemia	+	+		+							[22, 76, 83]
Lung cancer	+	+		+	+						[22, 76, 84, 85]
Melanoma	+	+		+	+	+*	+*				[22, 29, 76]
Multiple myeloma	+				+						[86]
Neuroblastoma		+		+							[87]
Non-Hodgkin’s lymphoma	+	+		+							[88]
Osteosarcoma	+	+		+	+						[89]
Ovarian cancer				+							[22, 76]
Pancreatic cancer				+							[90, 91]
Prostate cancer		+									[22, 74, 76]
Renal cell carcinoma		+									[22, 76]
Synovial sarcoma		+		+	+						[76]
Thyroid cancer		+									[22, 76]
Normal testis tissue	+	+	+	+	+		+	+	+		[29, 73]

*Only observed in cell lines.