Review Article

Immunotherapy for Renal Cell Carcinoma

Table 3

DC-based immunotherapy.

AuthorsAntigenDCAdjuvantPatientsDuration of PFS/RFSResults

Oosterwijk-WakkaAuto lysateAuto imDCKLH/IL-2128 SD, 4 PD
MartenAuto lysateAuto mDCKLH151 PR, 7 SD, 7 PD
HoltlAuto & Allo lysateAuto mDCKLH2720.4 mo2 CR, 1 PR, 7 SD, 17 PD
AzumaAuto lysateAuto imDCKLH31 NC, 2 PD
MartenDC/auto tumor fusionAllo mDC124 SD, 8 PD
Sutumor RNAAuto imDC10not evaluated
GitlizAuto lysateAuto imDC121 PR, 3 SD, 8 PD
BarbutoDC/auto tumor fusionAllo mDC195.7 mo30 R, 14 SD, 2 PD
AviganDC/auto tumor fusionAuto imDCKLH134.2 mo5 SD, 8 PD
PandhaAllo lysateAuto imDCKLH52 SD
ArroyoAuto lysateAuto mDCKLH59.6 mo (5–16)3 SD
HoltlAuto & Allo TuLyAllo mDCKLH/Cy2022.3 mo2 MR, 3 SD, 15 PD
WiereckyMUC-1 peptideAuto mDCPADRE2010.8 mo (4–24)1 CR, 2 MR, 2 PR, 5 SD, 10 PD
BleumerCA9 peptideAuto mDCKLH CA9 class II peptide66 PD
WeiDC/auto tumor fusionAuto mDCIL-2107 mo (5–12)1 PR, 3 SD, 6 PD
MatsumotoAuto lysateAuto mDCKLH31 SD, 2 PD
KimAuto lysateAuto mDCKLH95.2 mo1 PR, 5 SD, 3 PD
BerntsenLysate or surviving and telomerase peptidesAuto mDCIL-2272.7 mo13 SD, 14 PD
TatsugamiAuto TuLyAuto mDCIFN-α77.8 mo5 SD, 2 PD
ZbouDC/auto tumor fusionAllo mDC101 PR, 6 SD, 3 PD

Cy: cyclophosphamide, PADRE: pan-MHC class II binding peptide, Auto mDC: autologous mature DC, Allo imDC: allogeneic immature DC CR: complete response, PR: partial response, MR: mixed response, SD: stable disease, OR: objective response, PD: progressive disease, PFS: progression-free survival, RFS: recurrence-free survival.