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Clinical and Developmental Immunology
Volume 2010, Article ID 410893, 9 pages
http://dx.doi.org/10.1155/2010/410893
Research Article

CpG Oligodeoxynucleotides Enhance the Efficacy of Adoptive Cell Transfer Using Tumor Infiltrating Lymphocytes by Modifying the Th1 Polarization and Local Infiltration of Th17 Cells

1Department of Immunology, Zunyi Medical College, Guizhou 563003, China
2Department of Chest Medicine, Qingdao Chest Hospital, Shandong 266043, China
3Institute for Immunobiology and Department of Immunology, Shanghai Medical College, Fudan University, Shanghai 200032, China
4Department of Medical Physics, Zunyi Medical College, Guizhou 563003, China
5Department of Cardiothoracic Surgery, East Hospital, Tongji Unversity School of Medicine, Shanghai 200120, China
6Department of Respiratory Medicine, East Hospital, Tongji Unversity School of Medicine, 150 Jimo Road, Pudong New Area, Shanghai 200120, China
7Department of Scientific Research, East Hospital, Tongji Unversity School of Medicine, Shanghai 200120, China

Received 29 June 2010; Revised 13 September 2010; Accepted 26 September 2010

Academic Editor: Chaim Putterman

Copyright © 2010 Lin Xu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Adoptive cell transfer immunotherapy using tumor infiltrating lymphocytes (TILs) was an important therapeutic strategy against tumors. But the efficacy remains limited and development of new strategies is urgent. Recent evidence suggested that CpG-ODNs might be a potent candidate for tumor immunotherapy. Here we firstly reported that CpG-ODNs could significantly enhance the antitumor efficacy of adoptively transferred TILs in vivo accompanied by enhanced activity capacity and proliferation of T cells and T cells, as well as a Th1 polarization immune response. Most importantly, we found that CpG-ODNs could significantly elevate the infiltration of Th17 cells in tumor mass, which contributed to anti-tumor efficacy of TILs in vivo. Our findings suggested that CpG ODNs could enhance the anti-tumor efficacy of adoptively transferred TILs through modifying Th1 polarization and local infiltration of Th17 cells, which might provide a clue for developing a new strategy for ACT based on TILs.