CpG Oligodeoxynucleotides Enhance the Efficacy of Adoptive Cell Transfer Using Tumor Infiltrating Lymphocytes by Modifying the Th1 Polarization and Local Infiltration of Th17 Cells
Figure 1
CpG-ODNs treated TILs reduced tumor burden and prolonged nude mice survival. TILs were collected from lung cancer patients () and treated with CpG-ODNs or control CpG-ODNs as described in Materials and Methods. autologous TILs were transferred into lung cancer bearing Balb/c nude mice with 100 ug CpG-ODNs or control CpG-ODNs through tail vein. The tumor growth of each group was measured and the survival time of tumor bearing nude mice was calculated. One representative data from 26 individual patients with lung cancer was shown (a). Each bar represents the means (SD) from 6 nude mice in each group. The survival rate from all 26 individual patients was also calculated (b). .
