[Retracted] NKT Cells in Sepsis

Table 1

Summary of proposed role of NKT cells in experimental models of sepsis.

Experimental model	Role of NKT Cells	Reference
Generalized Schwartzman reaction	Deleterious: anti-NK1.1 Ab-treated, 𝛽2m^−/− and 𝐽𝛼281^−/− mice were protected	[19, 20]
Endotoxemia (single i.v. LPS injection)	Deleterious: 𝐽𝛼18^−/− mice were protected	[21]
	No role: 𝛽2m^−/− and 𝐽𝛼18^−/− mice were more susceptible to LPS-induced shock	[22]
Polymicrobial sepsis (cecal ligation and puncture)	Deleterious:
	(a) pretreatment with anti-CD1d blocking Ab decreased septic mortality	[23]
	(b) 𝛽2m^−/− mice treated with anti-asialo GM1 Ab and 𝐽𝛼18^−/− mice had improved survival	[24, 25]
	No role: CD1-KO mice exhibited no significant difference in survival; mice depleted of NK cells were protected	[26]