Long-Term Follow-Up of HLA-A2+ Patients with High-Risk, Hormone-Sensitive Prostate Cancer Vaccinated with the Prostate Specific Antigen Peptide Homologue (PSA146-154)

Table 3

Differentially expressed genes between immune responders and nonresponders*.

Gene name (symbol)	Probe set	Fold change	Affected immune-function associated pathway
2^′-5^′ oligoadenylate synthetase 1 (OAS1)	202869_at; 205552_s_at	4.05; 2.48	Innate immune response
Vannin 1 (VNN1)	205844_at	2.74	Innate immune response; Positive regulation of T-cell differentiation in the thymus
Sh2 domain containing 1B (SH2D1B)	1553176_at	1.92	Natural killer cell mediated cytotoxicity
DEAD box polypeptide 58 (DDX58)	218943_s_at	1.82	Innate immune response
Interferon-induced transmembrane protein 3 1–8 U (IFITM3)	212203_x_at	1.55	Immune response
Mitogen-activated protein kinase 1 (MAPK1)	1552263_at; 1552264_a_at	1.53; 1.37	T-cell and B-cell receptor signaling; VEGF signaling pathway TGF-beta signaling; natural killer mediated cytotoxicity; CCR3 signaling in eosinophils; CXCR4 signaling pathway
CD58 molecule (CD58)	216942_s_at; 205173_x_at	1.46; 1.48	IL-17 signaling pathway
X-ray repair complementing defective repair in Chinese hamster cells 4 (XRCC4)	210813_s_at	1.38	T-cell differentiation in the thymus; Immunoglobulin V(D)J recombination
Tumor necrosis factor receptor superfamily, member 25	211841_s_at	0.65	Cytokine-cytokine receptor interaction
Chemokine C-C motif receptor 7 (CCR7)	206337_at	0.52	Cytokine-cytokine receptor interaction
Phosphoinositide-3-kinase, regulatory subunit 1 alpha (PIK3R1)	212249_at	0.62	T-cell activation; T-cell and B-cell receptor signaling; CXCR4 signaling pathway; VEGF signaling pathway; Toll-like receptor signaling pathway
Epiregulin (EREG)	205767_at	0.26	positive regulation of innate immune response

Gene expression analysis was performed on unmanipulated pre-vaccination PBMC. *Of the 166 genes differentially expressed, only genes affecting the immune function associated pathway are shown.