Research Article

Cytokine Production by Peripheral Blood CD4+ and CD8+ T Cells in Atopic Childhood Asthma

Table 4

Percentage of CD4+ T cells and CD8+ T cells producing IL-2, IL-4, IL-10, IL-13, INF-γ, and TNF-α before and after in vitro activation with phorbol 12-myristate-13-acetate and ionomycin in the four groups of asthmatics (1-intermittent, 2-mild persistent, 3-moderate persistent, and 4-severe persistent asthma). In parenthesis, the frequencies of spontaneous cytokine staining (in the presence of monensin alone) are presented.

Subgroups of asthma patients
persistent asthma
1-intermittent
n-10
2-mild
n-14
3-moderate
n-12
4-severe
n-4

CD4+/IL-2+
( )

( )

( )

( )
CD4+/IL-4+
( )

( )

( )

( )
CD4+/IL-10+
( )

( )


( )
CD4+/IL-13+
( )

( )

( )

( )
CD4+/IFN-γ +
( )

( )

( )

( )
CD4+/TNF-α +
( )

( )

( )

( )
CD8+/IL-2+
( )

( )

( )

( )
CD8+/IL-4+
( )

( )

( )

( )
CD8+/IL-10+
( )

( )

( )

( )
CD8+/IL-13+
( )

( )

( )

( )
CD8+/IFN-γ +
( )

( )

( )

( )
CD8+/TNF-α +
( )

( )

( )

( )

severe persistent asthma versus intermittent asthma.
severe persistent asthma versus moderate persistent asthma.
-values from Mann-Whitney U-test.
Data as shown as mean ± SE.