Vaccines and Immunotherapeutics for the Treatment of Malignant Disease

Table 2

FDA approved monoclonal antibodies for use in cancer therapy.

Antibody	Target	Developer	Approved cancer treatments
Rituximab	CD20	IDEC Pharmaceuticals	Non-Hodgkin lymphoma
Trastuzumab	ErbB2	Genentech/UCLA	Breast
Gemtuzumab ozogamicin	CD33	Wyeth	Acute myeloid leukemia
Alemtuzumab	CD52	Genzyme Corporation	Chronic lymphocytic leukemia
Ibritumomab tiuxetan	CD20	IDEC Pharmaceuticals	Non-Hodgkin lymphoma
^131I-tositumomab	CD20	Corixa	Non-Hodgkin lymphoma
Cetuximab	EGFR	ImClone Systems	Colorectal, head/neck
Bevacizumab	VEGF	Genentech	Colorectal
Panitumumab	EGFR	Amgen	Colorectal

Abbreviations: EGFR, epidermal growth factor receptor; VEGF; vascular endothelial growth factor.