Interleukin-15 Affects Patient Survival through Natural Killer Cell Recovery after Autologous Hematopoietic Stem Cell Transplantation for Non-Hodgkin Lymphomas

Table 4

Univariate analysis for overall and progression-free survival.

Cytokines	Overall survival 𝑃-value	Progression-free survival 𝑃-value
IL-1b	.08	.1
IL-1ra	.2	.4
IL-2	.09	.1
IL-4	.03	.02
IL-5	.8	.3
IL-6	.07	.08
IL-7	.06	.06
IL-8	.01	.04
IL-9	.1	.2
IL-10	.02	.04
IL-12p70	.06	.06
IL-13	.06	.06
IL-15	<.0001	<.001
IL-17	.09	.1
Eotaxin	.4	.02
FGF	.2	.3
G-CSF	.06	.06
GM-CSF	.06	.06
IFN-G	.04	.06
IP-10	.4	.5
MCP-1	.1	.2
MIP-1a	.008	.008
MIP-1b	.07	.1
PDGF	.004	<.002
RANTES	.6	.7
TNF-𝛼	.007	.006
VEGF	.4	.3
Age ≥ 60	.16	.06
A-ALC	.01	.004
ALC-15	<.0004	<.0001
CD34	.3	.8
Disease status at transplant: complete remission	.11	.1
Extra nodal sites ≥ 2	.46	.8
LDH; abnormal	.3	.2
Mono-15	<.001	<.002
NK-15	<.0002	<.0002
PS > 1	.24	.81
Stage III/IV	.2	.28

Interleukin (IL)-1b, IL-1ra, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12p70, IL-13, IL-15, IL-17, Eotaxin, fibroblast growth factor (FGF), granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), interferon-gamma (IFN-G), interferon-gamma-inducible protein 10 (IP-10), monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory proteins 1a and 1b (MIP-1a and MIP-1b), platelet-derived growth factor (PDGF), RANTES, tumor-necrosis-factor-gamma (TNF-G), vascular endothelial growth factor (VEGF), autograft absolute lymphocyte count (A-ALC), absolute lymphocyte count at day 15 post transplant (ALC-15), lactate dehydrogenase (LDH), absolute monocyte count at day 15 post transplant (Mono-15), natural killer cells at day 15 post transplant (NK-15), and performance status (PS).