Review Article
More Than Just Tumor Destruction: Immunomodulation by Thermal Ablation of Cancer
Table 5
Studies reporting immune modulation in cancer patients and animal models treated with HIFU.
| | Species | Tumor | Model | Immunologic effect | References |
| | Human | Breast carcinoma () | | HSP-70 (membrane)↑ | [122] | | Breast carcinoma () | | CD3+, CD4+, CD8+ cells (tumor)↑ | [27] | | | | CD20+ cells (tumor)↑ | | | | | CD57+ cells (tumor)↑ | | | Pancreatic carcinoma () | | NK cells (blood)↑* | [123] | | Uveal melanoma () | | CD4+ cells (blood)↑ | [125] | | Osteosarcoma () | | CD4+ cells (blood)↑ | [126] | | HCC () | | | | | RCC () | | | |
| | Mouse (Ajax) | Neuroblastoma | C1300 ± adriamycin | Tumor growth (rechallenge)↓ | [136] |
| | Mouse (C57BL/6J) | HCC | H22 ± DC | Activation of CD8+ cells (spleen)↑ | [124] | | | | Tumor growth (rechallenge)↓ | | | | H22 ± tumor lysate vaccine | Cytolytic activity (spleen)↑ | [121] | | | | Tumor growth (rechallenge)↓ | |
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*NK cell phenotype was not specified.
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