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Clinical and Developmental Immunology
Volume 2011 (2011), Article ID 174149, 9 pages
http://dx.doi.org/10.1155/2011/174149
Review Article

Immune Microenvironment in Colorectal Cancer: A New Hallmark to Change Old Paradigms

1Clinical Oncology Department, Hospital Universitario Virgen Macarena, Avenida Dr. Fedriani s/n, 41009 Sevilla, Spain
2Clinical Oncology Department, Hospital Universitario Ramón y Cajal, Carretera de Colmenar Viejo, Km 9,100, 28034 Madrid, Spain

Received 30 June 2011; Accepted 16 September 2011

Academic Editor: Guido Kroemer

Copyright © 2011 Luis de la Cruz-Merino et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Impact of immune microenvironment in prognosis of solid tumors has been extensively studied in the last few years. Specifically in colorectal carcinoma, increased knowledge of the immune events around these tumors and their relation with clinical outcomes have led to consider immune microenvironment as one of the most important prognostic factors in this disease. In this review we will summarize and update the current knowledge with respect to this intriguing and complex new hallmark of cancer, paying special attention to infiltration by T-infiltrating lymphocytes and their subtypes in colorectal cancer, as well as its eventual clinical translation in terms of long-term prognosis. Finally, we suggest some possible investigational approaches based on combinatorial strategies to trigger and boost immune reaction against tumor cells.