A Functional Polymorphism in B and T Lymphocyte Attenuator Is Associated with Susceptibility to Rheumatoid Arthritis
Table 2
Association of 590A/C and 800T/C SNPs of human BTLA gene with susceptibility to autoimmune diseases.
590A/A
590A/C
590C/C
P
RR (95% CI)
Healthy subjects
61/71 (85.9%)
10/71 (14.1%)
0/71 (0.0%)
RA
56/81 (69.1%)
24/81 (29.6%)
1/81 (1.3%)
6.010
.014
2.19 (1.13–4.24)
SLE
55/64 (85.9%)
9/64 (14.1%)
0/64 (0.0%)
0.000
.997
1.00 (0.43–2.30)
SS
51/60 (85.0%)
9/60 (15.0%)
0/60 (0.0%)
0.022
.882
1.07 (0.46–2.45)
800T/T
800T/C
800C/C
Healthy subjects
36/71 (50.7%)
29/71 (40.8%)
6/71 (8.5%)
RA
45/87 (51.7%)
32/87 (36.8%)
10/87 (11.5%)
0.533
.766
0.98 (0.71–1.35)
SLE
35/56 (62.5%)
18/56 (32.1%)
3/56 (5.4%)
1.843
.398
0.76 (0.50–1.15)
SS
33/55 (60.0%)
16/55 (29.1%)
6/55 (10.9%)
1.885
.390
0.81 (0.54–1.21)
Genotyping of #590 and #800 SNPs of human BTLA gene was performed as described in Section 2. RA: rheumatoid arthritis, SLE: systemic lupus erythematosus, SS: Sjögren’s syndrome, RR: relative risk, CI: confidence interval.
