Review Article

Innate Immune Effectors in Mycobacterial Infection

Figure 2

Recognition of mycobacteria by pattern recognition receptors. Several pattern recognition receptors, such as NOD-like receptors and C-type lectin receptors, mediate the TLR-independent recognition of mycobacteria. NOD2, a member of NOD-like receptors, recognizes mycobacterial N-glycolyl MDP within the cytoplasm. DC-SIGN and dectin-1 are members of C-type lectin receptors, which are implicated in the recognition of mycobacteria. In addition, Mincle has been shown to recognize TDM (a mycobacterial cell wall glycolipid).
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