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Clinical and Developmental Immunology
Volume 2011, Article ID 353510, 8 pages
Review Article

Lymph Node Transplantation and Its Immunological Significance in Animal Models

Institute of Functional and Applied Anatomy, Hannover Medical School, 30625 Hannover, Germany

Received 13 January 2011; Accepted 22 March 2011

Academic Editor: K. Blaser

Copyright © 2011 Manuela Buettner and Ulrike Bode. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Lymph nodes (LNs) are distributed all over the body and whatever the site consists of the same cell populations. However, there are great differences between LN from different draining areas. For example, in mesenteric LN, homing molecules, for example, CCR9 and α4β7 integrin, were induced and cytokines, for example, IL-4, were produced on higher levels compared to peripheral LN. To study the immunological functions of LN, LN transplantation was performed in some specific areas using different animal models. Many groups investigated not only the regeneration of transplanted LN but also the induction of immune responses or tolerance after transplantation. Existing differences between LNs were still detectable after transplantation. Most important, stromal cells of the LN were identified as responsible for these differences. They survive during regeneration and were shown to reconstruct not only the structure of the new LN but also the microenvironment.