Journal of Immunology Research / 2011 / Article / Tab 3

Clinical Study

Modulation of Cytokine and Cytokine Receptor/Antagonist by Treatment with Doxycycline and Tetracycline in Patients with Dengue Fever

Table 3

Differential effect of Doxycycline and Tetracycline on cytokine levels and IL1-RA and S TNF-R1 in patients with dengue fever and dengue hemorrhagic fever.

Dengue fever (GMT and ranges, pg/mL)DHF (GMT and ranges, pg/mL)

DoxycyclineTetracyclineDoxycyclineTetracycline

Day 3Day 7Day 3Day 7Day 3Day 7Day 3Day 7

IL-65.983.96*6.365.483.84*2.36*4.684.23
(3.70–7.98)(2.32–6.89)(4.72–7.90)(3.89–7.07)(2.01–6.73)(1.24–5.38)(2.93–6.98)(2.46–6.66)
IL-1 2.29*1.55*3.362.235.32*3.29*7.687.22
(1.23–4.12)(1.10–2.78)(1.48–5.43)(1.02–4.69)(3.21–8.53)(1.21–6.48)(5.59–9.44)(5.21–9.32)
IL-1 RA673*964*330404710*996*517510
(486–851)(701–1459)(201–732)(231–920)(462–928)(703–1532)(342–695)(342–714)
TNF2.42*0.90*3.893.315.31*4.31*7.837.54
(0.23–4.63)(0.4–3.02)(2.03–5.65)(1.19–5.08)(0.46–12.32)(1.04–7.94)(5.99–9.62)(5.71–9.17)
TNF R12432*2616211523241961*2367*17361853
(673–3762)(1021–4412)(1358–3282)(1409–3974)(1538–2985)(1759–3129)(1329–2116)(1365–2362)

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