Involvement of Indoleamine 2,3-Dioxygenase in Impairing Tumor-Infiltrating CD8⁺ T-Cell Functions in Esophageal Squamous Cell Carcinoma

Table 1

Characteristics of 135 patients with esophageal squamous cell carcinoma and correlation between the clinicopathologic features and expression of IDO.

Characteristics	All cases (n)	IDO low n ( %)	IDO high n ( %)	Significance (P)*
Gender
Male	100	45 (45.0)	55 (55.0)	0.069
Female	35	22 (62.9)	13 (37.1)
Age (y)
<60	80	35 (43.8)	45 (56.2)	0.100
≥60	55	32 (58.2)	23 (41.8)
Stage
I-II	74	45 (60.8)	29 (39.2)	0.004
III-IV	61	22 (36.1)	39 (63.9)
Histological differentiation
Well	41	25 (61.0)	16 (39.0)	0.075
Moderate	57	22 (38.6)	35 (61.4)
Poor	37	20 (54.1)	17 (45.9)
Tumor diameter
<40mm	54	25 (46.3)	29 (53.7)	0.527
≥40mm	81	42 (51.9)	39 (48.1)
Depth of invasion
Submucosa	7	5 (71.4)	2 (28.6)	0.300
Muscularis propria	46	25 (54.3)	21 (45.7)
Adventitia	82	37 (45.1)	45 (54.9)
pT classification
T1-T2	44	28 (63.6)	16 (36.4)	0.024
T3-T4	91	39 (42.9)	52 (57.1)
pN classification
Yes	65	25 (38.5)	40 (61.5)	0.012
No	70	42 (60.0)	28 (40.0)
P metastasis
Yes	9	4 (44.4)	5 (55.6)	0.982
No	126	63 (50.0)	63 (50.0)
Intraepithelial CD8^+
High (≥10)	62	38 (61.3)	24 (38.7)	0.013
Low (<10)	73	29 (39.7)	44 (60.3)
Stromal CD8+
High (≥20)	66	42 (63.6)	24 (36.4)	0.001
Low (<20)	69	25 (36.2)	44 (63.8)