Research Article

Anti-IL-6 Receptor Antibody Causes Less Promotion of Tuberculosis Infection than Anti-TNF- 𝛼 Antibody in Mice

Figure 4

Histopathological analysis of mice 4 weeks after TB challenge. (a) Representative photomicrographs of lung tissues sections harvested from mice administered (a) anti-IL-6R Ab, (b) control Ab 1 (IL-6R), (c) anti-TNF-α Ab, or (d) control Ab 2 (TNF-α). Arrows indicate TB lesions including poorly defined granuloma-like lesions (×40, hematoxylin-eosin stain). (b) Pathologic TB lesion index in lungs. Results are the mean ± S.E.M. of triplicate samples from 5 mice per group. * by Student’s -test. N.S.: Not significant by Student’s -test. (c) Pathologic TB lesion index in liver. Results are the mean ± S.E.M. of triplicate samples from 5 mice per group. * by Student’s -test. N.S.: Not significant by Student’s -test.
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