Innate Immune Recognition of Mycobacterium tuberculosis

Figure 2

Pattern recognition receptors in the recognition of mycobacteria and downstream signaling pathways. Mycobacteria can be recognized through different pattern recognition receptors (PRRs) of the host. Both intracellular and extracellular receptors are involved in this process. After recognition of mycobacteria, intracellular signaling cascades are activated which eventually will lead to the activation of transcription of NF-κB. After transcription, the production of pro- and anti-inflammatory cytokines and chemokines is induced. The type of signaling cascade induced depends mainly on the type of PRR that recognizes (components of) MTB.