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Clinical and Developmental Immunology
Volume 2011 (2011), Article ID 430394, 14 pages
http://dx.doi.org/10.1155/2011/430394
Review Article

The Dendritic Cell-Regulatory T Lymphocyte Crosstalk Contributes to Tumor-Induced Tolerance

1Faculty of Medicine, INSERM UMR 866, IFR 100, 21000 Dijon, France
2Department of Pediatrics, Steele Children's Research Center, Department of Immunobiology, BIO5 Institute, and Arizona Cancer Center, The University of Arizona, Tucson, AZ 85724-5073, USA

Received 12 May 2011; Revised 30 August 2011; Accepted 31 August 2011

Academic Editor: Luigina Romani

Copyright © 2011 Nona Janikashvili et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Tumor cells commonly escape from elimination by innate and adaptive immune responses using multiple strategies among which is the active suppression of effector immune cells. Regulatory T lymphocytes (Treg) and tolerogenic dendritic cells play essential roles in the establishment and persistence of cancer-induced immunosuppression. Differentiating dendritic cells (DCs) exposed to tumor-derived factors may be arrested at an immature stage becoming inept at initiating immune responses and may induce effector T-cell anergy or deletion. These tolerogenic DCs, which accumulate in patients with different types of cancers, are also involved in the generation of Treg. In turn, Treg that expand during tumor progression contribute to the immune tolerance of cancer by impeding DCs' ability to orchestrate immune responses and by directly inhibiting antitumoral T lymphocytes. Herein we review these bidirectional communications between DCs and Treg as they relate to the promotion of cancer-induced tolerance.