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Clinical and Developmental Immunology
Volume 2011, Article ID 481439, 9 pages
http://dx.doi.org/10.1155/2011/481439
Review Article

Asbestos Induces Reduction of Tumor Immunity

1Department of Hygiene, Kawasaki Medical School, 577 Matsushima, Kurashiki 701-0192, Japan
2Division of Bioscience, Department of Biofunctional Chemistry, Okayama University Graduate School of Natural Science and Technology, 3-1-1 Tsushima-naka, Okayama 700-8530, Japan
3Division of Pneumoconiosis, School of Public Health, China Medical University, 92 North 2nd, Heping District, Shenyang 110001, China
4Department of Radiation Oncology, Kawasaki Medical School, 577 Matsushima, Kurashiki 701-0192, Japan

Received 15 June 2011; Accepted 18 July 2011

Academic Editor: E. Shevach

Copyright © 2011 Naoko Kumagai-Takei et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. “Asbestos scandal,” Nature, vol. 468, no. 7326, 868 pages, 2010.
  2. S. Kumagai and N. Kurumatani, “Mapping the risk of mesothelioma due to neighborhood asbestos exposure,” American Journal of Respiratory and Critical Care Medicine, vol. 178, no. 6, pp. 624–629, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. S. Kumagai and N. Kurumatani, “Asbestos fiber concentration in the area surrounding a former asbestos cement plant and excess mesothelioma deaths in residents,” American Journal of Industrial Medicine, vol. 52, no. 10, pp. 790–798, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. S. Kumagai, N. Kurumatani, T. Tsuda, T. Yorifuji, and E. Suzuki, “Increased risk of lung cancer mortality among residents near an asbestos product manufacturing plant,” International Journal of Occupational and Environmental Health, vol. 16, no. 3, pp. 268–278, 2010. View at Google Scholar · View at Scopus
  5. T. Yamanaka, F. Tanaka, S. Hasegawa et al., “A feasibility study of induction pemetrexed plus cisplatin followed by extrapleural pneumonectomy and postoperative hemithoracic radiation for malignant pleural mesothelioma,” Japanese Journal of Clinical Oncology, vol. 39, no. 3, pp. 186–188, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. S. Hasegawa and F. Tanaka, “Malignant mesothelioma: current status and perspective in Japan and the world,” General Thoracic and Cardiovascular Surgery, vol. 56, no. 7, pp. 317–323, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. R. Ohashi, K. Tajima, F. Takahashi et al., “Osteopontin modulates malignant pleural mesothelioma cell functions in vitro,” Anticancer Research, vol. 29, no. 6, pp. 2205–2214, 2009. View at Google Scholar · View at Scopus
  8. C. Tabata, N. Hirayama, R. Tabata et al., “A novel clinical role for angiopoietin-1 in malignant pleural mesothelioma,” European Respiratory Journal, vol. 36, no. 5, pp. 1099–1105, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Yasumitsu, C. Tabata, R. Tabata et al., “Clinical significance of serum vascular endothelial growth factor in malignant pleural mesothelioma,” Journal of Thoracic Oncology, vol. 5, no. 4, pp. 479–483, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. Y. Okumura, F. Tanaka, K. Yoneda et al., “Circulating tumor cells in pulmonary venous blood of primary lung cancer patients,” Annals of Thoracic Surgery, vol. 87, no. 6, pp. 1669–1675, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. F. Tanaka, K. Yoneda, N. Kondo et al., “Circulating tumor cell as a diagnostic marker in primary lung cancer,” Clinical Cancer Research, vol. 15, no. 22, pp. 6980–6986, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. H. Murakami, T. Mizuno, T. Taniguchi et al., “LATS2 is a tumor suppressor gene of malignant mesothelioma,” Cancer Research, vol. 71, no. 3, pp. 873–883, 2011. View at Publisher · View at Google Scholar
  13. Y. Sekido, “Inactivation of Merlin in malignant mesothelioma cells and the Hippo signaling cascade dysregulation,” Pathology International, vol. 61, no. 6, pp. 331–344, 2011. View at Publisher · View at Google Scholar
  14. Y. Goto, K. Shinjo, Y. Kondo et al., “Epigenetic profiles distinguish malignant pleural mesothelioma from lung adenocarcinoma,” Cancer Research, vol. 69, no. 23, pp. 9073–9082, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. S. Toyokuni, “Mechanisms of asbestos-induced carcinogenesis,” Nagoya Journal of Medical Science, vol. 71, no. 1-2, pp. 1–10, 2009. View at Google Scholar · View at Scopus
  16. S. Toyokuni, “Role of iron in carcinogenesis: cancer as a ferrotoxic disease,” Cancer Science, vol. 100, no. 1, pp. 9–16, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. Q. Hu, S. Akatsuka, Y. Yamashita et al., “Homozygous deletion of CDKN2A/2B is a hallmark of iron-induced high-grade rat mesothelioma,” Laboratory Investigation, vol. 90, no. 3, pp. 360–373, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. S. Toyokuni, “Iron as a target of chemoprevention for longevity in humans,” Free Radical Research. In press.
  19. H. Nagai and S. Toyokuni, “Biopersistent fiber-induced inflammation and carcinogenesis: lessons learned from asbestos toward safety of fibrous nanomaterials,” Archives of Biochemistry and Biophysics, vol. 502, no. 1, pp. 1–7, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. J. E. Craighead, A. I. Gibbs, and F. Pooley, “Mineralogy of asbestos,” in Asbestos and Its Diseases, J. E. Craighead and A. R. Gibbs, Eds., pp. 23–38, Oxford University Press, New York, NY, USA, 2008. View at Google Scholar
  21. V. L. Roggli and P. Coin, “Mineralogy of asbestos,” in Pathology of Asbestos-Associated Diseases, V. L. Roggli, T. D. Oury, and T. A. Sporn, Eds., pp. 1–16, Springer Science and Business Media, New York, NY, USA, 2nd edition, 2004. View at Google Scholar
  22. C. L. Uber and R. A. McReynolds, “Immunotoxicology of silica,” Critical Reviews in Toxicology, vol. 10, no. 4, pp. 303–319, 1982. View at Google Scholar · View at Scopus
  23. K. Steenland and D. F. Goldsmith, “Silica exposure and autoimmune diseases,” American Journal of Industrial Medicine, vol. 28, no. 5, pp. 603–608, 1995. View at Google Scholar · View at Scopus
  24. H. Reyes, E. A. Ojo-Amaize, and J. B. Peter, “Silicates, silicones and autoimmunity,” Israel Journal of Medical Sciences, vol. 33, no. 4, pp. 239–242, 1997. View at Google Scholar · View at Scopus
  25. D. D'Cruz, “Autoimmune diseases associated with drugs, chemicals and environmental factors,” Toxicology Letters, vol. 112-113, pp. 421–432, 2000. View at Publisher · View at Google Scholar · View at Scopus
  26. M. D. Mayes, “Epidemiologic studies of environmental agents and systemic autoimmune diseases,” Environmental Health Perspectives, vol. 107, no. 5, pp. 743–748, 1999. View at Google Scholar · View at Scopus
  27. J. Schreiber, D. Koschel, J. Kekow, N. Waldburg, A. Goette, and R. Merget, “Rheumatoid pneumoconiosis (Caplan's syndrome),” European Journal of Internal Medicine, vol. 21, no. 3, pp. 168–172, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. T. Otsuki, Y. Miura, Y. Nishimura et al., “Alterations of Fas and Fas-related molecules in patients with silicosis,” Experimental Biology and Medicine, vol. 231, no. 5, pp. 522–533, 2006. View at Google Scholar · View at Scopus
  29. T. Otsuki, M. Maeda, S. Murakami et al., “Immunological effects of silica and asbestos,” Cellular and Molecular Immunology, vol. 4, no. 4, pp. 261–268, 2007. View at Google Scholar · View at Scopus
  30. P. Wu, Y. Miura, F. Hyodoh et al., “Reduced function of CD4+25+ regulatory T cell fraction in silicosis patients,” International Journal of Immunopathology and Pharmacology, vol. 19, no. 2, pp. 357–368, 2006. View at Google Scholar · View at Scopus
  31. T. Otsuki, H. Hayashi, Y. Nishimura et al., “Dysregulation of autoimmunity caused by silica exposure and alteration of Fas-mediated apoptosis in T lymphocytes derived from silicosis patients,” International Journal of Immunopathology and Pharmacology, vol. 24, supplement 1, pp. 11S–16S, 2011. View at Google Scholar
  32. H. Hayashi, Y. Miura, M. Maeda et al., “Reductive alteration of the regulatory function of the CD4+CD25+ T cell fraction in silicosis patients,” International Journal of Immunopathology and Pharmacology, vol. 23, no. 4, pp. 1099–1109, 2010. View at Google Scholar
  33. R. Rolston and D. Oury, “Other neoplasia,” in Pathology of Asbestos-Associated Diseases, V. L. Roggli, T. D. Oury, and T. A. Sporn, Eds., pp. 217–230, Springer Science and Business Media, New York, NY, USA, 2nd edition, 2004. View at Google Scholar
  34. R. A. Lemen, “Epidemiology of asbestos-related diseases and the knowledge that led to what is known today,” in Asbestos, Risk Assessment, Epidemiology, and Health Effects, R. F. Dodson and S. P. Hammared, Eds., pp. 201–308, CRC Press, Taylor and Francis Group, Boca Ratton, Fla, USA, 2006. View at Google Scholar
  35. J. E. Craughea, “Nonthoracic cancers possibly resulting from asbestos exposure,” in Asbestos and Its Diseases, J. E. Craighead and A. R. Gibbs, Eds., pp. 230–252, Oxford University Press, New York, NY, USA, 2008. View at Google Scholar
  36. J. C. Barrett, P. W. Lamb, and R. W. Wiseman, “Multiple mechanisms for the carcinogenic effects of asbestos and other mineral fibers,” Environmental Health Perspectives, vol. 81, pp. 81–89, 1989. View at Google Scholar · View at Scopus
  37. J. M. Davis, “Mineral fibre carcinogenesis: experimental data relating to the importance of fibre type, size, deposition, dissolution and migration,” IARC Scientific Publications, no. 90, pp. 33–45, 1989. View at Google Scholar · View at Scopus
  38. I. Miyoshi, I. Kubonishi, S. Yoshimoto, and Y. Shiraishi, “A T-cell line derived from normal human cord-leukocytes by co-culturing with human leukemic T-cells,” Gann, vol. 72, no. 6, pp. 978–981, 1981. View at Google Scholar · View at Scopus
  39. I. Miyoshi, I. Kubonishi, S. Yoshimoto et al., “Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukaemic T cells,” Nature, vol. 294, no. 5843, pp. 770–771, 1981. View at Google Scholar
  40. F. Hyodoh, A. Takata-Tomokuni, Y. Miura et al., “Inhibitory effects of anti-oxidants on apoptosis of a human polyclonal T-cell line, MT-2, induced by an asbestos, chrysotile-A,” Scandinavian Journal of Immunology, vol. 61, no. 5, pp. 442–448, 2005. View at Publisher · View at Google Scholar · View at Scopus
  41. G. Liu, R. Beri, A. Mueller, and D. W. Kamp, “Molecular mechanisms of asbestos-induced lung epithelial cell apoptosis,” Chemico-Biological Interactions, vol. 188, no. 2, pp. 309–318, 2010. View at Publisher · View at Google Scholar · View at Scopus
  42. B. Fubini and A. Hubbard, “Reactive oxygen species (ROS) and reactive nitrogen species (RNS) generation by silica in inflammation and fibrosis,” Free Radical Biology and Medicine, vol. 34, no. 12, pp. 1507–1516, 2003. View at Publisher · View at Google Scholar · View at Scopus
  43. D. Upadhyay and D. W. Kamp, “Asbestos-induced pulmonary toxicity: role of DNA damage and apoptosis,” Experimental Biology and Medicine, vol. 228, no. 6, pp. 650–659, 2003. View at Google Scholar · View at Scopus
  44. A. Shukla, M. Gulumian, T. K. Hei, D. Kamp, Q. Rahman, and B. T. Mossman, “Multiple roles of oxidants in the pathogenesis of asbestos-induced diseases,” Free Radical Biology and Medicine, vol. 34, no. 9, pp. 1117–1129, 2003. View at Publisher · View at Google Scholar · View at Scopus
  45. Y. Miura, Y. Nishimura, H. Katsuyama et al., “Involvement of IL-10 and Bcl-2 in resistance against an asbestos-induced apoptosis of T cells,” Apoptosis, vol. 11, no. 10, pp. 1825–1835, 2006. View at Publisher · View at Google Scholar · View at Scopus
  46. Y. Miura, Y. Nishimura, M. Maeda et al., “Immunological alterations found in mesothelioma patients and supporting experimental evidence,” Environmental Health and Preventive Medicine, vol. 13, no. 2, pp. 55–59, 2008. View at Publisher · View at Google Scholar · View at Scopus
  47. S. Murakami, Y. Nishimura, M. Maeda et al., “Cytokine alteration and speculated immunological pathophysiology in silicosis and asbestos-related diseases,” Environmental Health and Preventive Medicine, vol. 14, no. 4, pp. 216–222, 2009. View at Publisher · View at Google Scholar · View at Scopus
  48. M. Maeda, Y. Nishimura, N. Kumagai et al., “Dysregulation of the immune system caused by silica and asbestos,” Journal of Immunotoxicology, vol. 7, no. 4, pp. 268–278, 2010. View at Publisher · View at Google Scholar · View at Scopus
  49. J. Wenzel and T. Tüting, “An IFN-associated cytotoxic cellular immune response against viral, self-, or tumor antigens is a common pathogenetic feature in "interface dermatitis",” Journal of Investigative Dermatology, vol. 128, no. 10, pp. 2392–2402, 2008. View at Publisher · View at Google Scholar · View at Scopus
  50. R. M. Strieter, M. D. Burdick, J. Mestas, B. Gomperts, M. P. Keane, and J. A. Belperio, “Cancer CXC chemokine networks and tumour angiogenesis,” European Journal of Cancer, vol. 42, no. 6, pp. 768–778, 2006. View at Publisher · View at Google Scholar · View at Scopus
  51. M. Maeda, Y. Nishimura, H. Hayashi et al., “Reduction of CXCR3 in an in vitro model of continuous asbestos exposure on a human T-cell line, MT-2,” American Journal of Respiratory Cell and Molecular Biology. In press.
  52. M. Maeda, Y. Nishimura, H. Hayashi et al., “Decreased CXCR3 expression in CD4+ T cells exposed to asbestos or derived from asbestos-exposed patients,” American Journal of Respiratory Cell and Molecular Biology. In press.
  53. Y. Nishimura, Y. Miura, M. Maeda et al., “Impairment in cytotoxicity and expression of NK cell-activating receptors on human NK cells following exposure to asbestos fibers,” International Journal of Immunopathology and Pharmacology, vol. 22, no. 3, pp. 579–590, 2009. View at Google Scholar · View at Scopus
  54. Y. Nishimura, M. Maeda, N. Kumagai, H. Hayashi, Y. Miura, and T. Otsuki, “Decrease in phosphorylation of ERK following decreased expression of NK cell-activating receptors in human NK cell line exposed to asbestos,” International Journal of Immunopathology and Pharmacology, vol. 22, no. 4, pp. 879–888, 2009. View at Google Scholar · View at Scopus
  55. Y. Nishimura, N. Kumagai, M. Maeda et al., “Suppressive effect of asbestos on cytotoxicity of human NK cells,” International Journal of Immunopathology and Pharmacology, vol. 24, supplement 1, pp. 5S–10S, 2011. View at Google Scholar