The Therapeutic Effect of Cytokine-Induced Killer Cells on Pancreatic Cancer Enhanced by Dendritic Cells Pulsed with K-Ras Mutant Peptide
Figure 6
The cytotoxicity of K-ras-DCCIK, DCCIK, CIK, and CTL induced by K-ras pulsed DC against PANC-1 (K-ras+) and SW1990 (K-rasā) cells in vitro (experiment 2.7). The K-ras-DCCIKs, DCCIKs, CIKs, and CTLs induced by K-ras pulsed DCs used as effector cells. PANC-1 and SW1990 used as target cells. The killing effects on PANC-1 showed that group K-ras-DCCIK exceeded group CIK and group CTL remarkably (). However, there was no difference between group CIK and CTL (), (Figure 6(a)). The different killing effects on SW1990 demonstrated K-ras-DCCIKs, DCCIKs, and CIKs; all showed their killing effects on SW1990 cells and are higher than CTL (), (Figure 6(b)).
