IL-12 and Related Cytokines: Function and Regulatory Implications in Candida albicans Infection

Table 1

Summary of effects of deletion of selected cytokine genes on susceptibility to systemic and mucosal candidiasis in mice.

Gene deleted	Background	Oral/Gastrointestinal response	Systemic response	Reference
IFN-𝛾	BALB/c	No effect	No effect	[32]
IFN-𝛾	C57BL/6 × 129	Susceptible	Susceptible	[33]
IFN-𝛾	C57BL/6	ND*	Susceptible	[34]
IL-4	BALB/c	ND	No effect (early)	[27]
IL-4	BALB/c	No effect	No effect	[36]
IL-18	C57BL/6	ND	Susceptible	[35]
IL-12 (p40)	BALB/c	Susceptible	No effect	[37]
IL-12 (p40)	C57BL/6	ND	No effect	[35]
IL-12 (p40)	C57BL/6	Susceptible	No effect	[11]
IL-12 (p35)	C57BL/6	No effect	ND	[38]
IL-23 (p19)	C57BL/6	Susceptible	ND	[38]

^∗ND, not done.