Th1 Cytokine-Secreting Recombinant Mycobacterium bovis Bacillus Calmette-Guérin and Prospective Use in Immunotherapy of Bladder Cancer

Table 1

Cytokine- and chemokine-expressing rBCG strains.

Strain	Cytokine	Species	Immunological effect	Reference
IL-2 BCG (RBD)	IL-2	m	Th1 cyt prod, Antitumor, Cytotoxicity	[30, 100, 101]
IL-2 BCG (MAO)	IL-2	r	Th1 cyt prod	[100]
BCG-CI	IL-2	h	Anti-BCG	[102]
BCG-CII	IL-2	h	Anti-BCG	[102]
BCG-IL-2	IL-2	m	CI, Th1 & Th2 cyt prod	[103]
BCG-GM-CSF	GM-CSF	m	CI, Th1 & Th2 cyt prod, DC act, Anti-M.tb	[103, 104]
BCG-IFN-γ	IFN-γ	m	CI, Th1 & Th2 cyt prod, Anti-BCG	[103, 105]
rBCG/IL-2	IL-2	m	CI, Th1 cyt prod, Anti-BCG	[106–108]
rBCG-IL-2/GFP	IL-2	m	CI, Th1 cyt prod, Anti-BCG	[109]
rBCG (α-Ag-IL-2)	IL-2	m	Th1 cyt prod, Cytotoxicity	[28]
BCG-IFN-γ	IFN-γ	m	Th1 cyt prod, Anti-BCG	[110]
rBCG-IFN-α	IFN-α 2B	h	Th1 cyt prod, Cytotoxicity	[38, 111, 112]
rBCG/IL-18	IL-18	m	no clear effect	[108]
BCG IL-18	IL-18	m	Th1 & Th2 cyt prod	[113, 114]
BCG-hIL2MUC1	IL-2	h	CI, Th1 cyt prod, Antitumor	[95, 96]
rBCG-IFN-γ	IFN-γ	m	CI, Th1 cyt prod, Antitumor	[115]
rBCG-IL-18	IL-18	m	Th1 cyt prod, Anti-BCG, Cytotoxicity	[29, 30]
rBCG-huIL-2-ESAT6	IL-2	h	CI, Th1 cyt prod, Cytotoxicity, HI	[116]
rBCG-IL-2	IL-2	h	Th1 cyt prod	[112]
BCGMCP-3	MCP-3	m	CI, Anti-BCG	[117]
rBCG-AEI	IFN-γ	m	CI, HI, Anti-M.tb	[118]
rBCG-Ag85B-IL15	IL-15	m	CI, Th1 cyt prod, Anti-M.tb	[119]
rBCG-MVNTR4-CSF	GM-CSF	h	CI, Th1 cyt prod, Antitumor	[97, 99]
rBCG-MVNTR8-CSF	GM-CSF	h	CI, Th1 cyt prod, Antitumor	[97, 99]
rBCG-Ag85B-Esat6-TNF-α	TNF-α	m	CI, HI	[120]

Anti-BCG: anti-BCG infection; Anti-M.tb: anti-Mycobacterium tuberculosis infection; CI: cellular immunity; DC act: dendritic cell activation; h: human; HI: humoral immunity; m: mouse; r: rat; Th1 cyt prod: T helper type 1 cytokine production; Th2 cyt prod: T helper type 2 cytokine production.