HLA Class II Defects in Burkitt Lymphoma: Bryostatin-1-Induced 17 kDa Protein Restores CD4+ T-Cell Recognition
Figure 2
BL and B-LCL express similar levels of HLA class II pathway components. Variations in efficiency of Ag presentation between BL and B-LCL may be attributable to differences in expression levels of components in the class II pathway. To evaluate this possibility, the BL cell lines Nalm-6.DR4 and Ramos.DR4, the B-LCL cell lines 6.16.DR4.DM and Frev were analyzed by western blotting for expression of HLA class II, invariant chain (Ii), and HLA-DM (a). Densitometric analysis confirmed the expression of comparable levels of each of these class II pathway components (b).
