Allergic Bronchopulmonary Aspergillosis in Asthma and Cystic Fibrosis

Table 4

Genetic risk factors in the development of allergic bronchopulmonary aspergillosis.

(i) HLA-DR restriction and HLA-DQ protection
(1) HLA-DR2
(a) HLA-DRB1*1501 and *HLA-DRB1*1503
(2) HLA-DR5
(3) HLA-DQ2 protective, decreased in ABPA
(a) DQB1*0201
(ii) IL-4RA polymorphisms
(1) IL-4RA ile75val
(iii) IL-10 polymorphisms
(1) Promoter -1082 GG genotype
(iv) Surfactant protein A2 (SP-A2) polymorphisms
(1) SP-A2 ala91pro
(v) Cystic fibrosis transmembrane conductance regulator (CFTR) mutations
(1) Heterozygous CFTR mutations in asthmatic patients with ABPA
(vi) Toll-like receptor (TLR) polymorphisms
(1) TLR9 T-1237C polymorphism