Journal of Immunology Research / 2011 / Article / Tab 1

Review Article

PI3K Functions in Cancer Progression, Anticancer Immunity and Immune Evasion by Tumors

Table 1

Main effects of the PI3K and VEGFR inhibitors on immune cells.

PI3K inhibitorsp110 isoformVEGFR2/3 inhibitorsEffectRef.

PIK-75αReduced production of TNF-α and IL-6, reduced expression of human endothelial cell adhesion molecules (E-selectin, ICAM-1, and VCAM-1), and human monocyte-endothelial cell adhesion.[79]
AS-605240γReduced numbers of infiltrated proinflammatory macrophages and T cells.[80, 81]
AS041164γReduced RANTES-induced chemotaxis/recruitment.[82]
CAL-101δApoptosis of CLL cells and decreased production of various inflammatory and antiapoptotic cytokines by activated T cells.[72]
IC87114δReduced antigen-induced airway infiltration of inflammatory cells, secretion of T(H)2 cytokines in lungs, and inhibition of monocytic integrin activation during diapedesis.[83]
SU5416Reduced IFNγ secretion by CD4+ CD45RO+ T cells.[84]
E7080Reduced lymphocytes in tumor.[85]
TSU68Decreased expression of CXCL1 (by cancer cells) and IL-12 and reduced neutrophil migration into tumor.[86]

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