Review Article
Autoantibodies and Resident Renal Cells in the Pathogenesis of Lupus Nephritis: Getting to Know the Unknown
Table 1
Autoantibodies with pathogenic potential in patients with lupus nephritis.
| Autoantibodies | Prevalence (%) | Binding to kidney structure/resident renal cells | References |
| Anti-dsDNA | 70–96 | GBM | [29–31] | | | Mesangial cells | | | | Glomerular epithelial cells | | | | Glomerular endothelial cells | | | | Proximal tubular epithelial cells | | Anti-nucleosome | 60–90 | GBM | [29, 31, 32] | | | Mesangial cells | | | | Glomerular epithelial cells | | | | Glomerular endothelial cells | | Anti-Ro | 25–44 | GBM | [29, 33] | Anti-Smith | 10–60 | GBM | [29, 30, 33] | Anti-C1q | 40–97 | GBM | [29, 31, 34, 35] | | | Glomerulus | | | | Tubular basement membrane | | Anti-α-actinin | 20 | Glomerulus | [16, 17, 29, 36] | | | Mesangial cells | | | | Podocytes | | Anti-annexin II | 32–65 | Glomerulus | [18] | | | Mesangial cells | | Anti-ribosomal P protein | 75 | Glomerulus | [37, 38] | | | Mesangial cells | |
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