Review Article

Autoantibodies and Resident Renal Cells in the Pathogenesis of Lupus Nephritis: Getting to Know the Unknown

Table 1

Autoantibodies with pathogenic potential in patients with lupus nephritis.

AutoantibodiesPrevalence (%)Binding to kidney structure/resident renal cellsReferences

Anti-dsDNA70–96GBM[2931]
Mesangial cells
Glomerular epithelial cells
Glomerular endothelial cells
Proximal tubular epithelial cells
Anti-nucleosome60–90GBM[29, 31, 32]
Mesangial cells
Glomerular epithelial cells
Glomerular endothelial cells
Anti-Ro25–44GBM[29, 33]
Anti-Smith10–60GBM[29, 30, 33]
Anti-C1q40–97GBM[29, 31, 34, 35]
Glomerulus
Tubular basement membrane
Anti-α-actinin20Glomerulus[16, 17, 29, 36]
Mesangial cells
Podocytes
Anti-annexin II32–65Glomerulus[18]
Mesangial cells
Anti-ribosomal P protein75Glomerulus[37, 38]
Mesangial cells