Journal of Immunology Research / 2012 / Article / Tab 1

Research Article

The Development of Severe Neonatal Alloimmune Thrombocytopenia due to Anti-HPA-1a Antibodies Is Correlated to Maternal ABO Genotypes

Table 1

The maternal ABO type distribution in the pregnancies compared to the severity of NAIT.

Maternal ABO typeNumbers of newborns with platelet count <50 × 109/L (% within ABO type; 95% CI)Numbers of newborns with platelet count 50–150 × 109/LNumbers of newborns with platelet count >150 × 109/L value

A34 (46.6; 0.36–0.58)13260.005
O12 (20.0; 0.12–0.32)1434
B7 (38.9; 0.20–0.61) 110
AB1 (14.3; 0.03–0.51)15

Total 54 29 75

Relative risk of NAIT was 0.67 (95% CI 0.48–0.94) in neonates born of women with blood group O versus blood group A.
Relative risk of severe NAIT was 0.43 (95% CI 0.25–0.75) in neonates born of women with blood group O versus blood group A.
Chi-square test (two-sided) for frequencies of NAIT and severe NAIT in blood group O compared to blood group A.

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